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Sanford-Burnham Science Blog

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How you can join the Rally for Medical Research

by Heather Buschman, Ph.D. on April 8, 2013 at 5:10 am | 0 Comments
Full Article
RallyMedRes-6

Today, April 8, 2013, at 11 a.m. ET, thousands of patient and research advocates, survivors, researchers, clinicians, business leaders, and members of the general public will gather on the steps of the Carnegie Library in Washington, D.C., to Rally for Medical Research. The event, organized by the American Association for Cancer Research, calls on our nation’s policymakers to prioritize medical research funding. This is a unified call for sustained investment in the National Institutes of Health (NIH), an investment to improve health, spur progress, inspire hope, and save lives.

How can you participate?

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Rally for Medical Research: 8 reasons to support NIH funding

by admin on April 3, 2013 at 5:49 am | 0 Comments
Full Article
#RallyMedRes

#RallyMedRes

What: Rally for Medical Research
When: April 8, 2013, 11 a.m – 12:15 p.m. ET
Where: Carnegie Library, Washington, D.C. and webcast live at www.rallyformedicalresearch.org
On Twitter at #RallyMedRes

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Life science roundtable with Rep. Darrell Issa

by Heather Buschman, Ph.D. on March 25, 2013 at 10:46 am | 0 Comments
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Left to Right: Rep. Darrell Issa; Dr. Kristiina Vuori, Sanford-Burnham president and interim CEO; Greg Lucier, Life Technologies CEO (Photo by Augustine Agado, Life Technologies)

Left to Right: Rep. Darrell Issa; Dr. Kristiina Vuori, Sanford-Burnham president and interim CEO; Greg Lucier, Life Technologies CEO (Photo by Augustine Agado, Life Technologies)

San Diego is a hub for life science research. According to San Diego Regional EDC, the region is home to more than 600 life science companies and 80 research institutes, which employ more than 42,000 people. Much of this industry is located in California’s 49th Congressional District, represented by Congressman Darrell Issa, chairman of the House Oversight and Government Reform Committee. Last Friday, Rep. Issa sat down with many of San Diego’s life science leaders.

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The challenges of funding research

by Kristina Meek on October 13, 2012 at 7:05 am | 0 Comments
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Steve Clemons moderated a panel with (L to R) Debi Brooks, Dr. Santosh Kesari, and Greg Lucier

Steve Clemons moderated a panel with (L to R) Debi Brooks, Dr. Santosh Kesari, and Greg Lucier

The Atlantic Meets the Pacific, a two-day conference held in La Jolla, Calif. by The Atlantic magazine and UC San Diego, crescendoed with its final panel, titled “Truth is What Stands the Test of Experience: The Challenges of Scientific Research and Philanthropy.” If that seems like a mouthful, be assured the panelists were at no loss for words on the subject.

“I am a big believer in basic research,” said Greg Lucier, CEO of Life Technologies and former chair of Sanford-Burnham’s board of trustees. A leader in the biotechnology industry, Lucier expressed many of the same hopes and goals as his fellow panelists, a fundraiser and a researcher. Debi Brooks, co-founder and executive vice chairman of the Michael J. Fox Foundation, and Santosh Kesari, M.D., Ph.D., chief of the division of neuro-oncology at the UC San Diego School of Medicine, both expressed the need for increased funding for research. Moderator Steve Clemons, editor-at-large for The Atlantic, expressed his admiration for all that each of these three have accomplished for their own organizations, and for what those accomplishments mean for the greater good.

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NIH New Innovator Award helps Sanford-Burnham scientist pursue high-risk, high-reward project

by Heather Buschman, Ph.D. on September 13, 2012 at 6:01 am | 0 Comments
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Duc Dong, Ph.D.

Duc Dong, Ph.D.

The National Institutes of Health (NIH) Office of the Director today announced that Duc Dong, Ph.D., assistant professor at Sanford-Burnham Medical Research Institute (Sanford-Burnham), will receive a New Innovator Award. These awards are intended to help researchers pursue big ideas with the potential to transform scientific fields and speed the translation of research into improved health.

Dong’s big idea is to grow replacement organs in an adult animal, using a new technology his lab recently developed. He and his team will genetically reprogram cells in zebrafish to induce new tissue development. Zebrafish, a valuable model for studying human development and disease, will allow the researchers to rapidly screen genes and chemicals important for efficient genetic reprogramming in a living organism.

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NIH director Francis Collins calls for continued funding of basic medical research

by Patrick Bartosch on September 5, 2012 at 5:51 am | 0 Comments
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Dr. Francis Collins makes a compelling case for continued funding of basic medical research (Photo by National Institutes of Health)

Dr. Francis Collins makes a compelling case for continued funding of basic medical research (Photo by National Institutes of Health)

In an editorial for Science, Dr. Francis Collins, director of the U.S. National Institutes of Health (NIH), makes a convincing case for continued funding of basic medical research. In the editorial, Dr. Collins writes that the NIH will continue to support basic research, which it defines as systematic study directed toward fuller knowledge or understanding of the fundamental aspects of phenomena and of observable facts without specific applications in mind. According to the article:

“In this time of severe budget constraints, Americans need to know that today’s basic research is the engine that powers tomorrow’s therapeutic discoveries,” says Dr. Francis Collins. “They need to know that basic research is the type of science that the private sector, which requires rapid returns on investment, cannot afford to fund. They need to know that, because it is impossible to predict whence the next treatment may emerge, the nation must support a broad portfolio of basic research.”

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Immune system expert takes on leukemia and lymphoma

by Heather Buschman, Ph.D. on August 29, 2012 at 6:04 am | 2 Comments
Full Article
Carl Ware, Ph.D., director of Sanford-Burnham's Infectious and Inflammatory Disease Center

Carl Ware, Ph.D., director of Sanford-Burnham's Infectious and Inflammatory Disease Center

Carl Ware, Ph.D., director of Sanford-Burnham’s Infectious and Inflammatory Disease Center, was recently awarded a new five-year grant from the National Cancer Institute, part of the U.S. National Institutes of Health, to examine how a family of cellular communication proteins—called cytokines—are disrupted in lymphoma and leukemia.

Leukemia and lymphoma are types of blood cancers—they can affect a person’s bone marrow, blood cells, lymph nodes, or other parts of the lymphatic system. According to the Leukemia & Lymphoma Society, one person in the U.S. is diagnosed with a blood cancer approximately every four minutes. While the survival rate for people with leukemia and lymphoma has increased in recent years due to research and new treatments, approximately 53,000 Americans died from these cancers in 2011.

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Presidential advisor John P. Holdren visits Sanford-Burnham at Lake Nona

by Patrick Bartosch on April 4, 2012 at 2:13 pm | 0 Comments
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Dr. John P. Holdren tours Sanford-Burnham's Lake Nona site

Dr. John P. Holdren tours Sanford-Burnham's Lake Nona site

We’re always thrilled to have public officials visit our facilities in California and Florida, but last Friday was an especially exciting day for scientists and staff at Sanford-Burnham’s Lake Nona campus in Orlando, Fla. Dr. John P. Holdren, advisor to President Barack Obama, toured Orlando’s Medical City and spent time at the Sanford-Burnham site to learn about the promising research that is being conducted in our Diabetes and Obesity Research Center.

Dr. Holdren is assistant to President Obama for science and technology, director of the White House Office of Science and Technology Policy (OSTP), and co-chair of the President’s Council of Advisors on Science and Technology (PCAST). Congress established the OSTP in 1976 to advise the President and others within the Executive Office of the President on the effects of science and technology on domestic and international affairs. The OSTP also makes recommendations on the annual NIH budget.

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Why the economy depends on federal funding for medical research

by Patrick Bartosch on February 22, 2012 at 3:03 pm | 0 Comments
Full Article
NIH Funding

NIH funding is crucial for medical research

When Sanford-Burnham CEO John Reed, M.D., Ph.D. traveled to Washington, D.C., in early February, he attended a variety of Capitol Hill briefings to discuss the importance of National Institutes of Health (NIH) funding for medical research. He pointed out that NIH grants account for approximately 80 percent of all funding for non-profit medical research institutions in the United States, such as Sanford-Burnham.

NIH grants contribute to the ultimate goal of developing new treatments for diseases and improving the quality of life for millions of Americans and people worldwide. The research supported by these grants also generates U.S. patents that fuel the biotechnology industry and creates thousands of jobs across the nation. NIH funding supports the training of our biomedical research workforce and strengthens the foundation of a 21st century knowledge-based economy.

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Call Your Representative

by Josh Baxt on February 16, 2011 at 10:05 am | 4 Comments
Full Article

Let’s cut to the chase. The House of Representatives is considering a bill (HR 1) that would slash $1.6 billion from the National Institutes of Health (NIH)’s budget. That means there would be less funding for biomedical research, which means important investigations that might lead to new treatments would not take place.There are many reasons to oppose this legislation. The research funded by NIH grants eases human suffering. Between 1998 and 2007, 23 percent of new drugs originated in universities and research institutes supported by the NIH. Here are more than a few recent examples of research at Sanford-Burnham funded by NIH grants. Every day, our researchers make new discoveries with support from the NIH.

Beyond the moral issue of using our resources to help people, NIH funding has a profound impact on communities, including creating excellent jobs, supporting universities, generating spin-off companies (which in turn create more jobs) and other critical economic impacts.

The worst part is that these cuts will not save us money. They will cost us, both in the short and long run, especially the long run. For example, caring for people with Alzheimer’s disease is projected to cost $20 trillion over the next 40 years. The only possible solution is new, better treatments. And the only way we’re going to get there is by funding biomedical research.

Turning our backs now will be a very costly mistake, both in human suffering and economic impact. If you agree, please contact your Representative and encourage him or her to reject HR 1.

Where Structure Meets Function

by Heather Buschman, Ph.D. on September 30, 2010 at 10:06 am | 2 Comments
Full Article

The human genome project taught us a lot about the number and sequences of our genes, but not a whole lot about what they do. In the years since, scientists have been using that genomic information to examine the structures of proteins, the molecules that carry out our genes’ instructions (see DNA 101). Structural information is being used to answer biological questions about protein function – how they facilitate chemical reactions, carry molecular signals in and out of cells and control cellular movements. There’s a growing need to understand how multiple proteins work together to accomplish all that and more.As part of their Protein Structure Initiative (PSI), the National Institute of General Medical Sciences (NIGMS) at the National Institutes of Health has awarded a five-year, $6.8 million grant to a team led by Sanford-Burnham’s Dr. Robert Liddington and Stanford University’s Dr. W. James Nelson. PSI was formed in 1999 to help researchers establish the structure of more proteins, faster. Now in its third phase, called PSI:Biology, PSI structure determination centers are partnering with scientists like Dr. Liddington and Dr. Nelson to address important biological questions linking a protein’s structure and its function.

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Core Grant Renewal Continues a 30-Year Legacy

by Josh Baxt on September 28, 2010 at 3:39 pm | 0 Comments
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Sanford-Burnham’s Cancer Center has received a five-year core grant renewal from the National Cancer Institute (NCI). The renewal, which runs through 2015, will provide more than $21 million to support advanced cancer research, a 21 percent increase over the previous grant. Sanford-Burnham has been an NCI-designated basic research Cancer Center since 1981, one of only seven in the nation.

“NCI Cancer Center designation is a national benchmark, and our renewal with an “outstanding” rating confirms the exceptional quality of cancer research at Sanford-Burnham,” says President Kristiina Vuori, M.D., Ph.D. “The significant budget increase we received is a tremendous honor and a reflection of the hard work and dedication by faculty and staff throughout the Institute.”

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Heart team gets pumped up

by Heather Buschman, Ph.D. on September 28, 2010 at 8:21 am | 0 Comments
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A collaborative team led by Dr. Gabriel Haddad at the University of California, San Diego (UCSD), which includes Sanford-Burnham’s Dr. Rolf Bodmer, Dr. Pilar Ruiz-Lozano, Dr. Karen Ocorr and Dr. Giovanni Paternostro, was awarded a $10 million grant from the National Heart, Lung, and Blood Institute, part of the National Institutes of Health. The team will research the molecular response to low oxygen levels – a condition known as hypoxia– in heart, lung and brain cells.

“This funding will allow us to develop powerful predictions of how the human heart and other organs can be protected from hypoxia-inflicted injury by studying both fruit flies, which are very tolerant to low oxygen, and mice, which are less tolerant,” explains Dr. Bodmer, professor and director of Sanford-Burnham’s Development and Aging Program.

According to Dr. Paternostro, adjunct assistant professor, ”This grant will allow us to continue our work on the systems biology and metabolomics of hypoxia, an ongoing collaboration with Dr. Haddad and with the other scientists participating in the funded project.”

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Big boost for HIV research

by Heather Buschman, Ph.D. on August 16, 2010 at 1:41 pm | 8 Comments
Full Article

A research team led by Dr. John Young, professor at the Salk Institute for Biological Studies, and Dr. Sumit Chanda, associate professor at Sanford-Burnham, was awarded a $21 million Program Project Grant from the National Institutes of Health (NIH). This funding will allow the team to analyze the innate immune response (the body’s earliest defenses) against HIV infection using a systems biology approach. This large-scale initiative aims to increase our understanding of all the body’s cellular and molecular factors that work together to respond to HIV-1 infection and how these factors influence a patient’s prognosis.

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A Coming Together of Cancer Centers

by Heather Buschman, Ph.D. on August 4, 2010 at 9:35 am | 0 Comments
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A group of top researchers from the University of Texas MD Anderson Cancer Center (MDACC) gathered with their Sanford-Burnham counterparts in La Jolla last week to seek ways the two Cancer Centers could collaborate to translate basic research into new medicines.

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